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  <xs:element id="mygn_EmployeeStockPurchasePlanTwentyTwelveMember" abstract="true" name="EmployeeStockPurchasePlanTwentyTwelveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingRightsAverageTradingDays" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingRightsAverageTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxReconciliationIncentiveStockOptionAndESPPExpenseAmount" abstract="false" name="EffectiveIncomeTaxReconciliationIncentiveStockOptionAndESPPExpenseAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxReconciliationIncentiveStockOptionAndESPPExpensePercent" abstract="false" name="EffectiveIncomeTaxReconciliationIncentiveStockOptionAndESPPExpensePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficerCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxRateReconciliationAcquisitionsAndDispositionsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationAcquisitionsAndDispositionsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_EffectiveIncomeTaxRateReconciliationAcquisitionsAndDispositions" abstract="false" name="EffectiveIncomeTaxRateReconciliationAcquisitionsAndDispositions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="mygn_DeferredTaxAssetsLeaseLiabilities" abstract="false" name="DeferredTaxAssetsLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_DeferredTaxAssetResearchAndExperimentalExpenseCapitalization" abstract="false" name="DeferredTaxAssetResearchAndExperimentalExpenseCapitalization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_DeferredTaxLiabilitiesLeaseRightOfUseAssets" abstract="false" name="DeferredTaxLiabilitiesLeaseRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_OtherStateMember" abstract="true" name="OtherStateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_WestSaltLakeCityMember" abstract="true" name="WestSaltLakeCityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="mygn_AdditionalAreaOfRealEstateProperty" abstract="false" name="AdditionalAreaOfRealEstateProperty" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="mygn_ChangeInOperatingLeaseRightOfUseAsset" abstract="false" name="ChangeInOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_ChangeInOperatingLeaseLiability" abstract="false" name="ChangeInOperatingLeaseLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_PurchasesOfPropertyPlantAndEquipmentAndCapitalizationOfInternalUseSoftwareInAccountsPayableAndAccruedLiabilities" abstract="false" name="PurchasesOfPropertyPlantAndEquipmentAndCapitalizationOfInternalUseSoftwareInAccountsPayableAndAccruedLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mygn_RashmiKumarMember" abstract="true" name="RashmiKumarMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
